Endocrine Abstracts

A 49 year old lady was investigated for palpitation and weight loss of 12 kg over 6 months. She was diagnosed thyrotoxic (TSH- not detectable; free thyroxine-66.4; normal: 12–22 pmol/L and triiodothyronine-8.6; normal: 1.3–3.1 nmol/L) and commenced on 40 mg of carbimazole. Ultrasound of thyroid showed multinodular goitre. Her systolic BP was low (100/70 mm Hg) and she felt tired. Her morning cortisol was 104 (normal; 220–700 nmol/L). A short synacthen test showe...

Silent and post-partum thyroiditis are autoimmune conditions, which result in a triphasic thyroid hormone disturbance. They are distinguished by the later condition’s relation to pregnancy. Their association in the same patient resulting in recurrent episodes of silent thyroiditis suggests a common aetiology.We report a 32-year-old female with post-partum and recurrent silent thyroiditis continuing over a decade. She presented post-partum with thyro...

We describe two cases of Conn’s syndrome both of whom had hyperprolactinaemia of which one was associated with pituitary adenoma, possibly as part of MEN 1.The first patient was a man aged 52 who presented with hypertension present for 10 years and a marginally low serum potassium. He was on doxazosin, lisinopril, candesartan and celiprolol. His Aldosterone/Renin ratio (8500:1) was very high suggestive of primary hyperaldosteronism. The patient was ...

A 34-year-old welder presented acutely unwell with a 2-week history of facial puffiness, swollen legs, and weight-gain. His GP had found him to be hypertensive and hypokalaemic and had commenced oral potassium supplements. Clinical examination revealed peripheral oedema (face and legs), BP was 179/100 mmHg, with no Cushingoid features. ECG and CXR were unremarkable. Tests showed leucocytosis but normal CRP, persistent hypokalaemia (2.5 mmol/l), normal venous bicarbonate and gl...